Gregory J. Tranah, PhD
Address: Suite 5700 185 Berry Street, San Francisco, CA 94107
Additional Websites: The Longevity Consortium
Dr. Tranah has extensive experience and training in molecular epidemiology of aging and age-related diseases. His current work involves the genetics of aging and age-related traits and he is engaged in research to discover the genes associated with longevity. Dr. Tranah is collaborating with investigators from the Study of Osteoporotic Fractures (SOF), the Study of Osteoporosis in Men (MrOS) and the Health, Aging and Body Composition Study to study the genetics of cognitive function, osteoporosis, osteoarthritis, sleep, circadian rhythms and the role of mitochondrial DNA in aging. Dr. Tranah is actively conducting genome wide association studies (GWAS) in the Health, Aging and Body Composition Study and is involved in several collaborations through the CHARGE GWAS consortium by actively participating in the following Working Groups: Musculoskeletal, Aging & Longevity, and Reproductive Aging/BMD. He is the PI of a candidate gene study examining the relationship between circadian and melatonin pathway genes and outcomes related to sleep, circadian rhythms, cognitive function, metabolism, and mortality. This work is being performed in two large population-based studies (SOF and MrOS). Dr. Tranah is also the PI of DNA resequencing studies examining the role of mitochondrial DNA mutations in both pancreatic cancer and human energetics. He is leading a deep sequencing study to identify rare sirtuin gene variants that are associated with surviving to >100 years and is pursuing studies of gene-environment interactions using both GWAS and sequence level data.
- Human genetics
- Mechanisms of aging
- Sleep and circadian rhythms
- Mitochondrial DNA: energetics, disease and aging
- Cancer epidemiology and genetics
- Tranah, G.J. 2010. Mitochondrial-Nuclear Epistasis: Implications for Human Aging and Longevity. Aging Research Reviews. In Press.
- Tranah GJ, N Parimi, T Blackwell, et al. 2010. Postmenopausal hormones and sleep quality in the elderly: a population based study. BMC Women's Health. Published Online: May 4, 2010.
- Tranah GJ, T Blackwell, S Ancoli-Israel, et al. 2010. Circadian activity rhythms and mortality: the Study of Osteoporotic Fractures. Journal of the American Geriatrics Society. 58(2):282-91.
- Paudel ML, BC Taylor, S Ancoli-Israel, et al. (includes GJ Tranah). 2010. Rest/Activity Rhythms and Mortality Rates in Older Men: MrOS Sleep Study. Chronobiology International. 27(2):363-377.
- Tranah GJ, EA Holly, PM Bracci. 2009. Solvent exposure and non-Hodgkin lymphoma: no risk in a population-based study in the San Francisco Bay Area. Cancer, Epidemiology, Biomarkers, Prevention. Nov;18(11):3130-2.
- Cluett C, MM McDermott, J Guralnik, et al. (includes GJ Tranah). 2009. The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet. Aug; 2(4):347-53.
- Tranah GJ, Taylor BC, Lui L, et al. 2008. Genetics of fracture risk and bone mineral density: the Study of Osteoporotic Fractures. Calcified Tissue International. Sep;83(3).
- Tranah GJ, PM Bracci, EA Holly. 2008. Domestic and farm-animal exposures and risk of non Hodgkin's lymphoma in a population-based study in the San Francisco Bay Area. Cancer, Epidemiology, Biomarkers, Prevention. Sep;17(9):2382-7.
- Meltzer D, JRB Perry, D Hernandez, et al. (includes GJ Tranah). 2008. A genome wide association study identifies protein quantitative trait loci (pQTLs). PloS Genet. May 9;4(5).
- Ogino S, A Hazra, GJ Tranah, GJ Kirkner, T Kawasaki, K Nosho, M Ohnishi, Y Suemoto, JA Meyerhardt, DJ Hunter, CS Fuchs. 2007. MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis: 28(9); 1985-1990.
- Tranah GJ, J Bugni, E Giovannucci, J Ma, C Fuchs, L Hines, L Samson, DJ Hunter. 2006. O6-methylguanine-DNA methyltransferase Leu84Phe and lle143Val polymorphisms and risk of colorectal cancer in the Nurses" Health Study and Physician's Health Study. Cancer, Causes & Control. 17:721-731.